If you have huge trace file with the following trace
 kgnfs_flushmsg:4808: CH OUT of ORDER SEND m->order 197816641 ch->order -1 ch 0xa0d530640
 kgnfs_flushmsg:4808: CH OUT of ORDER SEND m->order 197816642 ch->order -1 ch 0xa0d530640
Seems like you are hitting below bug:
Bug 16542886 - HUGE TRACE FILES WITH DNFS ERROR MESSAGES
Secure Configuration Guidelines for Oracle E-Business Suite 12.2 and 12.1 - We've been providing Oracle E-Business Suite secure configuration guidelines or best practices in our published MOS Notes and guides for some time now. Our...
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